Author

Joshua D. Welch

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Open access Sep 2026

LIGER2: Scalable Single-Cell Integration with On-Disk Datasets

Correcting batch effects and integrating single-cell sequencing datasets has been a crucial step in large-scale biological studies. Many methods have been published for this task, with complementary strengths in various scenarios. Our previous work, LIGER, leveraging integrative non-negative matrix factorization (iNMF)...

Yi-Chen Wang, Andrew Robbins, Gaurav T. Gadhvi et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

Genome-scale perturbation signatures from primary human CD4+ T cells improve genetics-based prioritization of immune drug targets

While human genetic evidence improves drug program success, target selection largely relies on associational features. Even functional features are mainly observational, capturing disease associations rather than the consequence of perturbing genes in the disease-relevant human cell type. To move beyond association, we...

Alexander L. Han, Max Slotnik, David A. Fox et al. · bioRxiv · 0 citations