Jun-Cheng Dai

Long-term exposure to fine particulate matter constituents and lung cancer risk in Chinese never-smokers.

Although long-term exposure to fine particulate matter (PM2.5) has been linked to lung cancer incidence in never-smokers (LCINS), evidence for PM2.5 constituents remains limited. This study included 262,785 never-smokers from the China Kadoorie Biobank, among whom 2646 LCINS cases were identified. Annual average concen...

Joint Effects of Metabolic Syndrome and Polygenic Risk Score on Lung Cancer Incidence and Mortality: A Prospective Cohort Study.

Joint Effects of Long-Term Obesity and Genetic Susceptibility on Sex-Specific Brain Aging.

These findings underscore long-term obesity as a critical, sex-dimorphic driver of accelerated brain aging, and midlife weight management offers robust neuroprotection even in genetically susceptible individuals.

Actionable genotypes beyond the coding sequence and their association with lifespan in the UK Biobank.

The findings demonstrate that functionally verified promoter variants represent a previously unrecognised determinant of mortality risk, highlighting the potential value of looking beyond coding sequences in future studies and provide clues that functional promoter variants may merit consideration when expanding action...

Large-scale whole-genome sequencing reveals the landscape and health implications of de novo mutations.

Paternal and maternal aging exhibited distinct mutational patterns, with maternal DNM accumulation accelerating at advanced ages, and in vitro embryo manipulation was associated with increased early post-zygotic mosaic mutations, particularly C > A substitutions linked to delayed neurocognitive development at 1 year.