Joint Effects of Metabolic Syndrome and Polygenic Risk Score on Lung Cancer Incidence and Mortality: A Prospective Cohort Study.

Associations of long-term PM2.5 exposure and genetic susceptibility with prevalent metabolic syndrome and subsequent cardiovascular disease risk: A UK Biobank cohort study.

Long-term PM2.5 exposure is implicated in cardiometabolic disorders, but its interactions with genetic susceptibility and the underlying epigenetic mechanisms remain unclear. We sought to examine the joint associations of long-term PM2.5 exposure and genetic susceptibility with prevalent metabolic syndrome (MetS) and s...

Blood Lead Levels and Mortality Risk in Cancer Patients: A Prospective Cohort Study with Mediation and Pan-Cancer Pathway Analysis.

Association of the Chinese visceral adiposity index with incident cardiovascular disease in cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study

Cardiovascular-kidney-metabolic (CKM) syndrome integrates metabolic abnormalities, chronic kidney disease, and cardiovascular disease (CVD), with stages 0–3 representing a critical window for primary prevention. Whether the Chinese visceral adiposity index (CVAI) adds predictive value for CVD in this population r...

Association of Cardiometabolic Index With Cardiometabolic Disease Prevalence and Mortality: Evidence From Two National Surveys.

BACKGROUND The cardiometabolic index (CMI), a composite marker derived from the product of waist-to-height ratio and triglyceride-to- high-density lipoprotein cholesterol ratio, has emerged as a potential indicator of metabolic risk. However, the prognostic value of the CMI across diverse populations and the continuum...

Prediction of All-Cause Mortality by Obesity Metabolic Phenotypes: A Waist Circumference-Driven Risk Stratification Study

Background and Aims: The limitations of body mass index (BMI) in assessing obesity-related mortality risk are increasingly apparent. This study investigates whether a risk stratification based on waist circumference (WC) and metabolic status provides a superior prediction of all-cause mortality and examines how age and...

Layered Effects of LDL-C Burden and Variability on Cardiovascular Events and Mortality in Type 2 Diabetes: A Nationwide Cohort Study.

In T2DM, LDL-C burden and variability jointly identified patients at greater risk, especially for MI and cardiovascular mortality, especially in younger adults or longer-duration diabetes subgroups.