Author

Jun-Jie Yang

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Sep 2026

SCAN: A sample-to-answer cross-priming isothermal assay for on-site virus detection with RT-qPCR sensitivity and genomically similar virus differentiation specificity.

Genomically similar viruses often differ in pathogenicity and host tropism due to specific mutations, and failure to distinguish them risks misdiagnosis and ineffective control. Molecular methods can differentiate such viruses but require laboratory settings and skilled personnel, while field-deployable immunological m...

Shu-Sen Ji, Li Ma, Jun-Jie Yang et al. · Talanta: The International J... · 0 citations

#protein folding Sep 2026

Self-Assembled PEDV Virus-Like Particle Nanovaccines Elicit Potent Neutralizing Antibodies and Confer Full Protection in Piglets.

Porcine epidemic diarrhea virus (PEDV) remains a major threat to the global swine industry, with current inactivated vaccines offering limited cross-protection due to imperfect antigen design and weak immune activation. Here, we engineered a full-structural-protein virus-like particle (VLP) co-assembled with PEDV S, M,...

Fei-Yang Jiang, Lian-Mei Bai, Yan-Yuan Zhang et al. · ACS Applied Materials and In... · 0 citations

Jul 2026

TOPS-CRISPR: Thermally-regulated and oligonucleotide-mediated one-pot CRISPR-Cas12a assay for ultra-sensitive and rapid on-site diagnostics.

A Thermally regulated, Oligonucleotide-mediated one-Pot System for CRISPR-Cas12a (TOPS-CRISPR), which employs a programmable inhibition strategy based on complementary RNA blockers with tunable length and binding sites, enabling efficient and reversible steric inhibition of the LbCas12a-crRNA ribonucleoprotein (RNP) co...

Shusen Ji, Bin Wang, Yi Yan et al. · Biosensors & bioelectronics · 0 citations