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Jun-Wei Yuan

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Feb 2026

Val325Met Mutation Affects N-glycosylation and Impairs the Function of Protein C

Background Protein C (PC) is a key anticoagulant protein that regulates hemostatic balance. Hereditary PC deficiency increases the risk of thrombosis. We identified the same mutation, c.1099G > A:p.V325 M (V325 M), in the PROC gene in four unrelated patients with thrombotic events and one patient with recurrent pregnan...

Shi-Jie Zhou, Jun-Wei Yuan, Xi Wu et al. · 0 citations
Jul 2026

Thrombomodulin Gly430Ser mutation attenuates the affinity with thrombin and contributes to thrombosis development.

The Gly430Ser mutation in TM compromises the thrombin dependent activation of PC and TAFI through impaired thrombin binding, underlying the hypercoagulable state and the increased risk of thrombosis observed in patients carrying this mutation.

Nifei Chen, Zhe Lai, Jun-Wei Yuan et al. · 0 citations

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