Thrombomodulin Gly430Ser mutation attenuates the affinity with thrombin and contributes to thrombosis development.

Nifei Chen Zhe Lai Jun-Wei Yuan Xi Wu Fang Li Q. Ding Wen-Man Wu Ying Song Xue-Feng Wang Jing Dai Xiao-Bo Hu Ye-Ling Lu

Jul 2026 · Journal of Thrombosis and Thrombolysis · 0 citations · 24 references

Medicine

TL;DR

The Gly430Ser mutation in TM compromises the thrombin dependent activation of PC and TAFI through impaired thrombin binding, underlying the hypercoagulable state and the increased risk of thrombosis observed in patients carrying this mutation.

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