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Author

Ying Song

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Jul 2026

Thrombomodulin Gly430Ser mutation attenuates the affinity with thrombin and contributes to thrombosis development.

The Gly430Ser mutation in TM compromises the thrombin dependent activation of PC and TAFI through impaired thrombin binding, underlying the hypercoagulable state and the increased risk of thrombosis observed in patients carrying this mutation.

Nifei Chen, Zhe Lai, Jun-Wei Yuan et al. · 0 citations

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