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Author

Junping Zhou

4 papers indexed here

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Sep 2026

Key enzyme optimization and multi-node metabolic flux regulation drive l-arginine production in Escherichia coli.

Microbial production of l-arginine is often constrained by tight metabolic regulation and insufficient precursor supply. Here a plasmid-free, non-auxotrophic Escherichia coli strain for high-level production of l-arginine was rationally engineered, based on our previous constructed strain G0 with 12.4 g/L l-arginine pr...

Xin Gao, An-Yi Wu, Zi-Teng Yang et al. · 0 citations
Sep 2026

Enhanced d -Pantothenic Acid Biosynthesis in Corynebacterium glutamicum by the CPSPC System and Spatial Organization Strategy

d-Pantothenic acid (D-PA) is an essential precursor of coenzyme A and the acyl carrier protein. Its biosynthesis requires abundant precursors and precise regulation of the multifunctional enzyme, ketopantoate reductase. Here, we engineered Corynebacterium glutamicum for enhanced D-PA production through metabolic engi...

Qing Yang, Bo Zhang, Liang-Gang Huang et al. · 0 citations
#protein folding Sep 2026

Enhancing d-Pantothenic Acid Production in Corynebacterium glutamicum via Integrating Dynamic Regulation With Structure-Guided Protein Engineering of Ketopantoate Reductase.

This study establishes a robust chassis for sustainable DPA production and provides a generalizable framework for engineering other valuable biochemicals.

Qing Yang, Tao-Shun Zhou, Bo Zhang et al. · 0 citations
Open access Aug 2026

Bee ovum-inspired hydrogel programs microenvironment remodeling for diabetic wound healing

Chronic diabetic wounds heal poorly due to a persistently imbalanced microenvironment involving inflammation and bacterial infection. Notably, oxidative stress, driven by mitochondrial damage, perpetuates inflammation and hinders repair. Existing therapeutic materials struggle to simultaneously address infection, infla...

Yanan Xue, Ying Lu, Yiran Lin et al. · 0 citations

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