Sep 2026
Microbial production of l-arginine is often constrained by tight metabolic regulation and insufficient precursor supply. Here a plasmid-free, non-auxotrophic Escherichia coli strain for high-level production of l-arginine was rationally engineered, based on our previous constructed strain G0 with 12.4 g/L l-arginine pr...
Xin Gao, An-Yi Wu, Zi-Teng Yang et al.
· Bioresource Technology · 0 citations
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Sep 2026
d-Pantothenic acid (D-PA) is an essential precursor of coenzyme A and the acyl carrier protein. Its biosynthesis requires abundant precursors and precise regulation of the multifunctional enzyme, ketopantoate reductase. Here, we engineered Corynebacterium glutamicum for enhanced D-PA production through metabolic engi...
Qing Yang, Bo Zhang, Liang-Gang Huang et al.
· ACS Synthetic Biology · 0 citations
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This study establishes a robust chassis for sustainable DPA production and provides a generalizable framework for engineering other valuable biochemicals.
Qing Yang, Tao-Shun Zhou, Bo Zhang et al.
· Biotechnology and Bioenginee... · 0 citations
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Open access
Aug 2026
Chronic diabetic wounds heal poorly due to a persistently imbalanced microenvironment involving inflammation and bacterial infection. Notably, oxidative stress, driven by mitochondrial damage, perpetuates inflammation and hinders repair. Existing therapeutic materials struggle to simultaneously address infection, infla...
Yanan Xue, Ying Lu, Yiran Lin et al.
· Materials Today Bio · 0 citations
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