Author

K. Arai

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#protein folding Oct 2026

From Folding Reagents to Catalysts: Spatially Organized Diselenide−Cyclodextrins Enable Catalytic Oxidative Protein Folding

Oxidative folding, involving disulfide (SS) bond formation and isomerization, is essential for the maturation of many secreted and membrane proteins. Although numerous small-molecule mimics of protein disulfide isomerase, a key enzyme that catalyzes oxidative folding, have been developed, most require superstoichiome...

Y. Iwata, Shunpei Iwamoto, Hiroki Takeda et al. · Biomacromolecules · 0 citations

Open access Jul 2026

Chemical Boosting of Foldase Condensates Accelerates Oxidative Protein Folding

Dynamic biomolecular condensates play crucial roles in intracellular compartmentalization and physiological functions. While engineering tools for compartmentalization have expanded add-on functionalities, directly amplifying the inherent catalytic machinery within biological phase-separated droplets has remained elusi...

Mai Watabe, Tsubura Kuramochi, Momoka Fukushima et al. · bioRxiv · 0 citations