Author

K. Beaumont

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#protein folding Open access Oct 2026

Molecular Consequences and Targeting of PPM1D Overexpression in Myeloproliferative Neoplasms.

Phosphatase Mg2+/Mn2+ dependent 1D protein (PPM1D) is a serine threonine phosphatase known to regulate oncogenic pathways. PPM1D mutations are enriched in therapy-related MDS and AML, but the role of PPM1D in myeloproliferative neoplasms (MPN) remains largely unexplored. By sequencing 519 MPN patients, we detected acti...

Md. Babu Mia, Christoph Schaniel, C. Clementelli et al. · Blood · 0 citations

Open access Aug 2026

Maternal and fetal cellular programs orchestrate pregnancy complications and placental tolerance

The placenta is a transient organ that orchestrates maternal-fetal interactions essential for healthy pregnancy, yet the multicellular principles governing placental dysfunction remain poorly understood. Here, we present a multimodal single-cell atlas of the human placenta, profiling over 1.2 million cells from 68 dono...

R. Normand, P. L. Lopez Zapana, L. Shook et al. · medRxiv · 0 citations

Open access Aug 2026

Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease

It is shown that a disease-associated microglial subtype, characterized by elevated GPNMB expression and enriched for polygenic AD risk, expands with AD pathology and shows increased phagocytic activity, and MITF is identified as an upstream regulator required to maintain this microglial state.

Donghoon Lee, James M. Vicari, Christian Porras et al. · Nature Genetics · 1 citation