Systematic Dissection of Key Driver Perturbation Signatures in Single Cells via ECCITE-seq.
Jing-Long Zhang, K. Brennand, Bin Zhang et al.
· Methods in molecular biology · 0 citations
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Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency
Loss-of-function mutation in the human gene dipeptidyl peptidase 9 (DPP9) causes Hatipoglu syndrome leading to severe inflammasomopathy. A key feature of the disease is pancytopenia, and patients require bone marrow transplantation, but the mechanism of cell loss is unclear, since Dpp9-mutant mice have normal hematopoi...
Tian-Li Xiao, J. R. Brewer, Maximillian J. Carlino et al.
· Journal of Clinical Investig... · 0 citations