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Author

K. Durinck

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Review Open access Aug 2026

A functional landscape for chromosome 17q in neuroblastoma: balancing replication stress and genomic stability.

Neuroblastoma is characterised by extensive genomic instability despite a marked paucity of recurrent somatic mutations. Instead, the disease is predominantly driven by chromosomal alterations, including segmental chromosomal imbalances, small structural variants, and oncogene amplification. A major unmet challenge is...

E. Hilgert, L. Depestel, N. Van Roy et al. · 0 citations
Jul 2026

SOX11 stimulates γδ T-cell differentiation and synergizes with LMO2 and MYCN to drive γδ-like T-cell acute lymphoblastic leukemia

Functional validation using genetic and transplantation-based mouse models demonstrated that SOX11 cooperates with MYCN to accelerate T-ALL onset and establish a cooperative SOX11–MYCN oncogenic axis driving γδ-like T-ALL.

André Almeida, Igor Fijalkowski, K. Christensen et al. · 0 citations

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