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SOX11 stimulates γδ T-cell differentiation and synergizes with LMO2 and MYCN to drive γδ-like T-cell acute lymphoblastic leukemia

André Almeida Igor Fijalkowski K. Christensen H. De Waele P. Pölönen Marlies Vanden Bempt Els Van Ammel S. T'Sas B. Lintermans Panagiotis Ntziachristos K. Durinck Frank Speleman Tom Taghon Jan Cools C. Mullighan D. Teachey P. Van Vlierberghe T. Pieters S. Goossens
Jul 2026 · bioRxiv · 0 citations · 4 references
Biology

TL;DR

Functional validation using genetic and transplantation-based mouse models demonstrated that SOX11 cooperates with MYCN to accelerate T-ALL onset and establish a cooperative SOX11–MYCN oncogenic axis driving γδ-like T-ALL.

DOI Semantic Scholar
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