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Author

K. Frederiksen

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Review Open access Sep 2026

Repeated clinical trial failures in Alzheimer's disease: The pitfalls of pursuing epidemiological associations.

Interventions for Alzheimer's disease (AD) have repeatedly been advanced from epidemiological associations, biological hypotheses and preclinical findings, yet many have failed in randomized trials and some have produced signals of clinical worsening. We examine illustrative successful and unsuccessful programs across...

B. Imbimbo, Nunzio Pomara, L. Pini et al. · 0 citations
#protein folding Open access Sep 2026

Epitope placement tunes CSF tau biomarkers: Comparison of P-tau217 and BD-tau designs

Results show that, irrespective of the partner antibody, phosphorylated tau assays are more accurate than assays that also measure non-phosphorylated forms of the protein in differentiating Aβ + from Aβ − individuals, and indicate that BD-pTau217 may offer superior sensitivity for the early identification of AD patholo...

H. Gleerup, C. S. Musaeus, Cristiano Santos et al. · 0 citations

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