K. Gokulakrishnan

Epigenome-Wide Placental Methylation Landscapes in Relation to Antenatal Depressive Symptoms.

Antenatal depressive symptoms (ADS) are common during pregnancy and are linked to adverse maternal and offspring neurodevelopmental outcomes. The placenta plays a central role in maternal-fetal communication and may function as an epigenetic sensor of maternal psychological stress. However, placental epigenetic signatu...

Epigenetic clues: Predicting maternal depression through DNA methylation.

Apo and substrate-bound dihydropteroate synthase crystal structures from Thermus thermophilus HB8.

High-resolution crystal structures of Thermus thermophilus HB8 DHPS and homologs from Escherichia coli and Mycobacterium tuberculosis highlight conserved catalytic features, as well as variable loop conformations and phosphate-binding residues that may contribute to differential sulfonamide sensitivity.