Author

K. Ohashi

3 papers indexed here

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Open access Sep 2026

Tarlatamab in small cell lung cancer following platinum-based chemotherapy: subgroup analysis of Japanese patients from the DeLLphi-304 study

In the Phase 3 DeLLphi-304 trial, tarlatamab significantly improved overall survival (OS) over chemotherapy for small-cell lung cancer (SCLC) progressed after platinum-based chemotherapy. We report efficacy and safety in the Japanese subpopulation. Patients were randomized to tarlatamab or amrubicin in Japan. The prima...

Takayasu Kurata, Shunichi Sugawara, Hiroaki Akamatsu et al. · International Journal of Cli... · 0 citations

Open access Sep 2026

Molecular characteristics and clinical outcomes of ERBB2-activating mutation-positive non-small cell lung cancer: A Japanese nationwide real-world cohort.

BACKGROUND Erb-b2 receptor tyrosine kinase 2 (ERBB2)-activating mutations are well-documented oncogenic drivers in non-small cell lung cancer (NSCLC), occurring in approximately 1-4% of cases. These alterations include a heterogeneous spectrum of variant subtypes; however, the clinicogenomic characteristics and clinica...

Masahiro Yamashita, K. Ninomiya, Shuta Tomida et al. · European Journal of Cancer · 0 citations

#protein folding Open access Sep 2026

Conformational stability and domain‐specific structural features of tumor autoantigens regulate autoantibody epitope propensity

It is established that the autoantibody epitope propensity is closely associated with the thermodynamic stability of the target autoantigen and provide a rational basis for tailoring antigen preparation strategies for autoantibody‐based cancer diagnosis.

Ai Miyamoto, Rika Yamamoto, Ryui Sakaguchi et al. · Protein Science · 0 citations