The bacterial cell cycle is an ensemble of integrated pathways that coordinates cell growth and division. Although these pathways contain a suite of promising antimicrobial targets, their functional organization and interrelationships have only been sparsely mapped. Here, we established a dual-CRISPRi platform for syst...
Sumana Bhowmick, Félix Ramos-León, K. Ramamurthi et al.· bioRxiv· 0 citations
A newly discovered family of microbial autoproteolytic domains suggests that bacteria and animals may share a common strategy for responding to physical forces, including adhesion, nutrient acquisition, virulence, and surface interactions.
It is demonstrated that the Bacillus subtilis protein ShfA localizes to the forespore by using an intramembrane lipid-binding domain to directly recognize undecaprenyl phosphate, a universal lipid carrier essential for cell wall synthesis.
V. Pande, Taylor B. Updegrove, V. Anantharaman et al.· Proceedings of the National...· 0 citations
It is shown that biofilm formation and sporulation instead diverge along a branched pathway, which emerges through a branched developmental program in which sporulating cells generate the cue that creates the biofilm-producing lineage via cell-cell communication through repurposing of a canonical intracellular metaboli...
Taylor B. Updegrove, V. Pande, Fukang She et al.· Science Advances· 1 citation
It is proposed that MraW modification of 16S rRNA enhances translation efficiency in general, and that specific transcripts have evolved structural features that fine-tune protein levels that may be prevalent in bacteria which exhibit uncoupled transcription and translation.
Zachory M. Park, Christina R. Savage, Amanda R. Decker-Farrell et al.· Cell Reports· 0 citations
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