Open access
Aug 2026
Disease-linked mutations in hnRNPA2B1 accelerate condensate maturation and promote amyloid aggregation
The results identify a sequence-encoded mechanism linking disease-associated mutations to altered condensate behavior and amyloid aggregation, providing molecular insights into how aberrant phase transitions may contribute to hnRNPA2B1-associated disease.
L. F. Durán-Armenta, Rani Van der Eecken, Annelore Stroobants et al.
· bioRxiv · 0 citations