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Disease-linked mutations in hnRNPA2B1 accelerate condensate maturation and promote amyloid aggregation

L. F. Durán-Armenta Rani Van der Eecken Annelore Stroobants K. Wahni J. Messens Dominique Maes Remy Loris Peter Tompa

Aug 2026 · bioRxiv · 0 citations · 44 references

Biology

TL;DR

The results identify a sequence-encoded mechanism linking disease-associated mutations to altered condensate behavior and amyloid aggregation, providing molecular insights into how aberrant phase transitions may contribute to hnRNPA2B1-associated disease.

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