Author

Kailong Li

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#gene editing Open access Sep 2026

Structure-guided discovery and engineering of miniature CRISPR-Cas12m for epigenome editing.

CRISPR-based epigenome editing represents a programmable strategy to precisely modulate gene expression, holding promise for therapeutic applications. However, the large size of dCas proteins substantially impedes delivery using adeno-associated virus (AAV) vectors. Here, through iterative bioinformatics analysis, stru...

Tao Yu, Meng Ji, Donglin Yu et al. · Nature Structural & Molecula... · 0 citations

Open access Aug 2026

TAL1 is indispensable in ETV2-primed human endothelial cell fate determination

It is demonstrated that ETV2 drives the rapid forward programming of human pluripotent stem cells (hPSCs) into endothelial cells (ECs) by direct remodeling of endothelial-specific enhancers and is established as a master gatekeeper of human EC specification.

Yun Zhao, Mengze Sun, Zi-Xuan Hong et al. · Science Advances · 0 citations