Kamal Obbad

Systematic mapping of enhancers, silencers, and topological elements with prime editing deletion screens

Noncoding regulatory elements in the human genome can control gene expression through distinct mechanisms, including acting as enhancers, silencers, or topological elements. However, we lack tools to identify all such classes systematically and quantify their effects on gene expression in an endogenous genomic context....

Estrogen interactions with breast cancer risk variants in regulatory DNA

Targeting DNMT1 augments anti-tumor CD8⁺ T cell function

DNMT1 targeting is established as a promising strategy to counteract CD8⁺ T cell exhaustion and potentiate ICI efficacy and enhances the effector function of melanoma patient-derived tumor infiltrating lymphocytes after prolonged ex vivo expansion.