The global rise in life expectancy has led to an increasing prevalence of age-related diseases, including neurodegenerative disorders, cancer, type 2 diabetes mellitus, and cardiovascular conditions, placing substantial societal and economic burdens on healthcare systems worldwide. A key mechanism underlying both aging...
Lukas Fresser, Zofia Chrienova, Jan Gebrt et al.· Frontiers in Pharmacology· 0 citations
It is reported that T‑2 toxin remodels APP and Tau homeostasis, featuring an early decrease in full‑length APP and a delayed, sustained increase in Tau phosphorylation and total Tau, accompanied by dynamic cytokine release.
Tong Nie, Junya Li, Shiqing Tan et al.· Neurotoxicology· 0 citations
This review critically evaluates the evidence base for AI-based toxicity prediction, assesses current challenges and considers the trajectory toward next-generation risk assessment, which requires adherence to the TREAT validation principles and sustained regulatory engagement.
Kamil Kuča, Siddhi Otari, Namrata Singh et al.· Archives of Toxicology· 0 citations
Several promising epidemiological trials linked high dietary intake of vitamins C and E to a reduced risk of Parkinson’s disease, and plant-derived antioxidants such as polyphenols were explored for their ability to combat neuroinflammation and reduce cognitive decline.
K. Jomová, S. Alomar, Richard Valko et al.· Archives of Toxicology· 0 citations
Fruits such as mango (Mangifera indica), apple (Malus × domestica ), tomato (Solanum lycopersicum), and strawberry (Fragaria × ananassa), are consumed worldwide and fall under a highly economical category of crops. In contrast, the postharvest management against fungal infections particularly remains a challenge for ma...
H. Kumar, Kamil Kuča, Nidhi Sethi et al.· Beni-Suef University Journal...· 0 citations
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