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Author

Karen Gu

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2 papers indexed here

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Open access Sep 2026

Upregulation of CD90 correlates with T lineage commitment at the DN2a stage of T cell development

Early thymic progenitors (ETPs) retain the potential for alternative fates but commit to the T-cell lineage as they progress through the CD4−CD8− double-negative (DN) thymocyte stages early in T-cell development. Current evidence suggests that T-lineage commitment occurs during the transition from the DN2a to DN2b stag...

Dhruti Parikh, Karen Gu, Sara Tomei et al. · 0 citations
#gene editing Open access Oct 2026

Dynamic phosphorylation of DGCR8 regulates embryonic stem cell differentiation and microprocessor function

The Microprocessor complex, minimally composed of DROSHA and DGCR8, is ubiquitously required for microRNA biogenesis. It also regulates the balance between pluripotency and differentiation through mRNA alternative splicing and mRNA cleavage. However, how these various activities are regulated remains incompletely und...

K. Leong, Lawrence Mok, Karen Gu et al. · 0 citations

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