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Author

Kari Alitalo

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Open access Oct 2026

Tie1 ectodomain cleavage governs vascular responses to inflammatory stimulation but is dispensable for angiogenic signaling

Ectodomain cleavage of the vascular receptor Tie1 distinguishes the inflammatory from the angiogenic functions of Angiopoietin-Tie signaling, mechanistically uncoupling two fundamental vascular programs.

Miki Kamiyama, Jing-Jing Shi, L. Rinck et al. · 0 citations
#gene editing Open access Oct 2026

Redirecting full-length FLT1 expression towards its soluble isoform by targeting alternative polyadenylation promotes postischaemic angiogenesis.

Using this mouse model, it is demonstrated that sFLT1 alone is sufficient for developmental vasculogenesis, whereas the specific loss of flFLT1 enhances reparative revascularization and angiogenesis and improves cardiac recovery after myocardial infarction.

M. Bundalo, Sandra Vorlová, Jessica Ulrich et al. · 0 citations
Open access Jul 2026

Progressive intestinal tumor cell plasticity, Myc activation, and loss of Lgr5+ tumor stem cell lineage commitment upon Wnt depletion

It is demonstrated that a plastic cell state (PCS) is present already in polyps from patients with familial adenomatous polyposis and in mouse intestinal adenomas, in which PCS is associated with PROX1+ tumor stem cells.

Marika Lassila, Fatemeh Seyednasrollah, Cinzia Bessone et al. · 0 citations

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