Author

Karla Martinez Pomier

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Open access Sep 2026

A cryptic symmetry switch allosterically controls how the PF4 self-protein turns into a pathogenic antigen

It is shown that cryptic conformational switches control PF4 tetramer asymmetry and how a benign self-protein morphs into an immunogenic antigen, triggering a pathogenic autoimmune response, overturning the long-standing hypothesis that electrostatics alone drive PF4 asymmetry.

Qiu-Lin Ma, Jin-Feng Huang, Ellen Mak et al. · Nature Communications · 0 citations

#protein folding Open access Sep 2026

Aortic disease-linked mutations reveal unexpected convergent allosteric mechanisms of protein kinase G misregulation

Using NMR, molecular dynamics simulations, and complementary kinase and binding assays, it is shown that Val234 acts as a crucial allosteric hub of PKG autoinhibition, explaining how distal mutations can unpredictably rewire kinase allostery and drive pathogenic vascular signaling.

Karla Martinez Pomier, Leopold Jahn, B. VanSchouwen et al. · Science Advances · 0 citations