Author

Katerina J. Williams

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#gene editing Open access Oct 2026

Prime editing enables high-throughput identification and characterization of selective MutSβ inhibitors

This effort identified a novel series of MutSβ inhibitors that reduced (CAG)n expansion in a cell model and established several methods for systematically interrogating MMR, with demonstrated capacity to identify inhibitors of therapeutic value.

Yangwode Jing, Jun Yan, Denny Yang et al. · bioRxiv · 0 citations

Open access Jul 2026

POGZ safeguards neuronal gene chromatin architecture and transcription

These results identify POGZ as a G9a/GLP-associated chromatin regulator that protects neurodevelopmental gene domains from heterochromatinization and perinuclear sequestering, preserving 3D architecture and transcription during cortical development.

N. Mariano, Katerina J. Williams, Katie Munechika et al. · bioRxiv · 0 citations