Author

Kelly J. Bouchonville

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Open access Oct 2026

Dihydropyrimidine Dehydrogenase Genotype-Phenotype Correlations in Plasma and Peripheral Blood Mononuclear Cells.

The chemotherapeutic 5-fluorouracil (5-FU) is commonly used to treat solid tumors, especially colorectal cancer. Deleterious variants in DPYD, which encodes dihydropyrimidine dehydrogenase (DPD), are strongly associated with severe and potentially lethal 5-FU toxicity. Phenotypic assays for DPD function have been propo...

Brianna M. Bembenek, Seid Hamzic, Kelly J. Bouchonville et al. · Clinical pharmacology and th... · 0 citations

PARTIAL ALTERNATIVE SPLICING IN CARRIERS OF DPYD rs75017182 EXPLAINS A MODEST ASSOCIATION WITH SEVERE

It is demonstrated that rs75017182‐ C promotes alternative splicing in the minigene plasmid model, and that the level of splicing may be affected by additional variants in linkage disequilibrium with rs75017182.

L. Hahn, Brianna M. Bembenek, Kelly J. Bouchonville et al. · 0 citations