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PARTIAL ALTERNATIVE SPLICING IN CARRIERS OF DPYD rs75017182 EXPLAINS A MODEST ASSOCIATION WITH SEVERE

L. Hahn Brianna M. Bembenek Kelly J. Bouchonville Steven M. Offer Pharmacotherapeutic SIGNIFICANCE. Dr Tolulope Oyetade O. Akinola Nanopore Amplicon Sequencing Wendy Wang Erin C. Boone David Joun J. Stevens L. Ramsey Stephani L. Stancil A. Gaedigk J. D. Stanton Jason Walker Ellie H. Jhun J. Hamilton Muneera Ali B. Rhead P. Velez C. Gignoux M. Perera Kyle Melín Abiel Roche Suraju Sadeeq J. Duconge Wen-Ding Wang B. Yoo Anmol Singh Mrinal Mishra Guang Yang C. Alarcon L. Yanek L. Becker N. Faraday T. O’Brien Matthew Tuck Li Gong Teri E. Klein David O. Meltzer J. Johnson L. Cavallari Edith Nutescu Sabrina Burkholder Alaa Radwan David P. Kao E. Hearst James Martin Nicole McDaniel Christina L. Aquilante Inienger Dr E. Ah Giuseppe Lo Hui-Xiang Chua D. Chua H. Toh Evelyn Shi Jie Tan Golda Wang Min Yi Gwee A. Lim Christina Jiun Yuchen Tan Siok Yi-Ko Lee Jing-Xuan Wen P. S. Wong Lawrence Siu-Chun Law. K. Lim Jishana Farhad DO Abdul Naseer Humphrey Hean Teik Ko B. Cher Goh Benjamin Yong-Qiang Tan Y. Wan Fathima Ashna Nastar Rangpa Taiju K. P. Leong Liuh Ling Teck Choon Tan K. Narasimhalu J. Ngeow Zewen Zhang K. Ngiam AProf H. Wee E. Tai J. D'Souza A. Miranda Christelle Lteif Rachel A. Myers Erica N. Elwood Elizabeth Harris Hrishikesh Chakraborty Paul R. Dexter Josh F. Peterson Renee A. Rider T. Skaar S. Volpi Julio D. Duarte COHORT. Mr. Vincent Nyangwara David Twesigomwe Neil Martinson A. Choudhury C. Masimirembwa African Farah Kidwai-khan Kathleen A. McGinnis C. Rentsch Amy C. Justice Forster Dr S. Sarkar A. Srinivasan
· 0 citations · 2 references

TL;DR

It is demonstrated that rs75017182‐ C promotes alternative splicing in the minigene plasmid model, and that the level of splicing may be affected by additional variants in linkage disequilibrium with rs75017182.

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