Author

Ken Y. Chan

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#protein folding Open access Sep 2026

BI-TfR1 CapX rapidly transits the blood-brain barrier for efficient, low-dose gene delivery throughout the CNS

Safe, efficient gene delivery throughout the CNS remains a central obstacle to treating genetic diseases of the brain and spinal cord. We describe BI-TfR1 CapX, a human transferrin receptor (TfR1)-binding AAV capsid that, after a low intravenous dose in adult humanized TFRC mice, transduced more than 80% of cortical an...

Ken Y. Chan, Chin-Yen Lin, Qin Huang et al. · bioRxiv · 0 citations

Open access Aug 2026

Comparative analysis of microglia-targeted AAVs reveals capsid choice drives efficiency in vitro but has limited impact in vivo

Improved capsids for in vitro manipulation of microglia are developed and viral genome design, not capsid identity, is established as the principal determinant of efficient in vivo microglial targeting.

Saša Jereb, Lia R. D’Alessandro, Nader Morshed et al. · bioRxiv · 0 citations