Author

Kerstin Otte

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#gene editing Open access Oct 2026

Same hydrolase knockouts, different outcomes: CRISPR/Cas9 editing workflow shapes resulting cellular phenotype and transcriptome in CHO

CRISPR/Cas9-based multi-gene knockout strategies are widely applied to engineer Chinese hamster ovary (CHO) cells, yet the impact of editing workflow on cellular outcomes remains poorly understood. Here, we systematically compare sequential and multiplex genome editing approaches to generate CHO cell lines lacking nine...

Linus Weiss, Stefan Schneider, Kerstin Otte et al. · Frontiers in Bioengineering... · 0 citations

Open access Aug 2026

Expanding Transposase Technology to Regulatory Noncoding RNAs for Stable Expression in CHO Cells

A transposase‐mediated platform for stable microRNA (miRNA) expression in CHO cells is established and the first application of a DNA transposon system for long‐term miRNA genome integration is demonstrated, demonstrating the applicability of transposase systems beyond protein‐coding transgenes.

Sonja Lochmueller, Linus Weiss, Kerstin Otte · Biotechnology Journal · 0 citations

Open access Jul 2026

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production.

The results demonstrate that transcriptomics-guided host-cell engineering is an effective strategy to identify and relieve intrinsic bottlenecks in stable LVV producer cell lines.

Jona Röscheise, Lena-Marie Eberle, Holger Laux et al. · Biotechnology and Bioenginee... · 0 citations