C-C chemokine receptor type 5 (CCR5) is the primary co-receptor mediating the entry of R5-tropic human immunodeficiency virus type 1 (HIV-1) into CD4+ T cells and macrophages, making it one of the most promising therapeutic targets in HIV cure research. The naturally occurring CCR5Δ32 mutation which abolishes surface C...
Mangroves are increasingly recognised as important nature-based systems for reducing coastal flood risk, yet research on their hydrodynamic performance remains dispersed across coastal engineering, eco-hydrology, restoration science, and environmental management. This study synthesises recent advances in mangrove-media...
Amayrol Zakaria, Khadijah Khalid, N. Khalili et al.· Sustainable Marine Structure...· 0 citations
The molecular mechanisms, preclinical evidence and emerging clinical data supporting CRISPR-based CCR5 disruption, including multiplex editing strategies designed to overcome viral tropism switching, and the evolving role of maraviroc beyond viral entry inhibition are examined.
