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T and B cell–mediated immunosurveillance of the central nervous system (CNS) can become maladaptive in multiple sclerosis (MS). Epstein–Barr virus (EBV) is a likely driver of MS, yet how exactly EBV-specific T cells contribute remains unclear. We generated an antigen-resolved atlas of blood and cerebrospinal fluid (CSF...
Diversity of epitope-specific TCRs is not limited by distinct germline combinations, but rather can emerge from a near-to-complete combinatorial space of α- and β-chain, V and J segments paired with compatible CDR3 sequences.
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