Author

L. B. Pedersen

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Open access Sep 2026

Primary cilia coordinate c-KIT signaling induced proliferation in alpha cells

Circulating glucagon levels are elevated in patients with diabetes and obesity and contribute to hyperglycemia. The mechanisms underlying hyperglucagonemia remain poorly understood, but expansion of pancreatic α-cell mass is thought to play an important role. Primary cilia are sensory organelles that act as signaling h...

Ganga Deshar, Mariam G. Aslanyan, Gaurav D. Diwan et al. · bioRxiv · 0 citations

Review Sep 2026

Primary cilia: master conductors of cellular communication in development and disease.

Emerging evidence indicates that cell-type-specific and temporally dynamic ciliary signatures determine signalling competence and disease susceptibility, and defining these signatures and the mechanisms that regulate their plasticity could lead to new therapeutic opportunities for ciliopathies and other cilia-associate...

O. K. Thomsen, Gaia Pigino, L. B. Pedersen et al. · Nature Reviews Nephrology · 0 citations

Open access Aug 2026

TAK1 operates at the primary cilium in non-canonical TGFB/BMP signaling to control heart development

A pivotal role is established for TAK1 and its upstream regulators at the primary cilium in heart development and syndromic CHD.

C. Doganli, O. K. Thomsen, Daniel A. Baird et al. · PLoS Biology · 5 citations

establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling

KIF13B is a novel regulator of ciliary TZ conﬁguration, membrane composition and Shh signalling and it is shown that KIF13B regulates TZ membrane composition and ciliary SMO accumulation.

K. Schou, J. B. Mogensen, S. Morthorst et al. · 0 citations