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Open access Sep 2026

Association of Polygenic Risk Score for Suicidal Behavior With Ventral Prefrontal Morphology in Bipolar Disorder.

BACKGROUND Bipolar disorder (BD) studies consistently implicate the ventral prefrontal cortex (VPFC) in association with suicidal behaviors. A suicidal behavior polygenic risk score (PRS) can now be computed to test whether elevated genetic risk for suicidal behavior is associated with variation in VPFC gray matter and...

Noa Katz Shroitman, D. Levey, Brian P. Pittman et al. · 0 citations
Open access Sep 2026

733. Effects of early life adversity on stress markers and emotion circuitry in adults with a history of suicide attempts

Abstract Background Early life adversity (ELA) has been highlighted as strong distal factor for emergence of suicide behaviors (SB), however not all persons that experience ELA will engage in SB. Dispositional factors, such as stress system responsivity, emotion dysregulation, and brain structure and connectivity are h...

L. Colic, A. Sankar, A. Zerekidze et al. · 0 citations
Open access Aug 2026

Cortical Thickness in Middle and Older Aged Adults With Bipolar Disorder Across Six International Sites

Older adults with bipolar disorder (BD) are at high risk for severe mood symptoms, cognitive difficulties, and early mortality; however, underlying brain alterations have received little study. Gray matter decreases in ventral prefrontal cortex (VPFC) seen in younger persons with BD, and additionally in dorsal PFC (DPF...

Rebecca B. Marks, A. Sankar, L. Colic et al. · 0 citations

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