Cortical Thickness in Middle and Older Aged Adults With Bipolar Disorder Across Six International Sites

Brain health strategies in middle-aged individuals with mild neurocognitive disorder: a scoping review

Highlights • Midlife mNCD provides a critical window for brain health risk modification.• Formalised interventions and self-directed strategies report benefits to cognitive function and psychological well-being.• Engagement with these strategies is influenced by a complex interplay of psychological, cognitive, and logi...

Specific basal ganglia, amygdala, and cortical neurons are associated with borderline personality disorder (BPD)

Borderline personality disorder (BPD) is clinically significant and poorly understood biologically. We tested which human brain cell types preferentially use genes associated with BPD, implicating two major types of neurons: LAMP5 interneurons and D2 medium spiny neurons. These interrogable cell types provide new avenu...

Children at familial high risk for schizophrenia or bipolar disorder show sex-specific differences in subcortical grey matter volumes

Background: Children of parents with schizophrenia (SZ) or bipolar disorder (BP) are at familial high risk (FHR) of developing severe mental illnesses. Based on findings in FHR populations and adults with SZ and BP, we hypothesized that children at FHR for schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) would show...

Subjective cognitive impairment: Towards early identification of Alzheimer disease (cid:2)

Social cognitive impairment across the bipolar disorder continuum: A comparative study of high-risk, first-episode, and chronic groups.

This study investigates whether social cognitive deficits in bipolar disorder (BD) represent static susceptibility markers, underlying differences in severity and vulnerability or graded, stage-related differences, thereby testing the clinical staging hypothesis. A healthy control (HC; n = 97) group was utilized as a n...

Association of Affective Temperaments With One‐Year Depressive Outcomes in Middle‐Aged and Older Patients With Mood Disorders Without Psychiatric Comorbidities

The course of depressive symptoms in mood disorders may be influenced by multiple clinical factors, making predictors of subsequent symptoms difficult to identify. This study examined whether affective temperaments are associated with depressive symptoms at one‐year follow‐up in middle‐aged and older patients with mood...