The human proteostasis network is operationally defined by providing a comprehensive, annotated, and manually curated list of its components classified into nine Branches based on their function and localization - cytonuclear proteostasis, ER proteostasis, mitochondrial proteostasis, nuclear proteostasis, proteostasis...
Evan T. Powers, Suzanne Elsasser, T. Stoeger et al.· Autophagy· 0 citations
The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Establishing and maintaining proteostasis is the province of the proteostasis network, a highly interconnected system of over 3000 components that regulate protein synthesis, folding, localization, and degradation....
Evan T. Powers, Suzanne Elsasser, Ee Phie Tan et al.· Autophagy· 0 citations
Most neurodegenerative diseases reflect patient-specific combinations of polygenic risk variants interacting with aging and environmental factors, rather than a single causative mutation. Phase III clinical trial failure rates for neurodegenerative indications exceed 95%, reflecting in part the limitations of existing...
Shi-Jie Wang, L. Elia, Wei-Yi Liu et al.· Journal of Clinical Investig...· 0 citations
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