Author

L. Hayann

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Review Open access Sep 2026

Overview of biophysical approaches to study osteogenic proteins in lipidic interfaces

Bone biomineralization is a tightly regulated process mediated by osteogenic proteins associated with extracellular vesicles known as matrix vesicles (MVs), which function as specialized nanoreactors for the nucleation and propagation of biological apatite. The activity of MV-associated proteins, including tissue-non...

L. Hayann, Maryanne T. Mello, J. G. Cominal et al. · Biophysical Reviews · 0 citations

#protein folding Open access Sep 2026

PHOSPHO1 deficiency delays osteogenic differentiation of osteoblasts, impairing mineralization and altering the protein composition of matrix vesicles.

It is indicated that cellular adaptation is insufficient to restore mineralization in the absence of PHOSPHO1, and instead, PHOSPHO1 appears to play a critical role in establishing the molecular and biophysical properties of MVs necessary for mineral nucleation and propagation.

L. H. S. Andrilli, L. Hayann, C. Tokuhara et al. · Bone · 0 citations