Author

Leonardo Lopiano

3 papers indexed here

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Open access Oct 2026

Digital Motor Profiling in Parkinson’s Disease: Long-Term Monitoring Through Wearable Sensors

Background/Objectives: Parkinson’s disease (PD) is clinically heterogeneous, and motor complications are often inadequately captured during routine outpatient assessments. In this cross-sectional observational study, we investigated whether prolonged home-based wearable monitoring could enable digital motor profiling b...

A. Zampogna, Luigi Borzì, Domiziana Rinaldi et al. · Brain Science · 0 citations

Open access Oct 2026

Timing of Deep Brain Stimulation and Cognitive Trajectories in GBA1-Associated Parkinson's Disease.

BACKGROUND Individuals with Parkinson's disease (PD) carrying GBA1 variants often develop advanced motor complications that prompt evaluation for deep brain stimulation (DBS). However, concerns about accelerated cognitive decline after DBS in GBA1 carriers complicate clinical decision making. A critical aspect that is...

E. Asimakidou, M. Avenali, J. Aasly et al. · Movement Disorders · 0 citations

Open access Jul 2026

Association of GBA1 status and sex with depression severity and progression in Parkinson's disease.

GBA1 variants increase neuropsychiatric vulnerability in Parkinson's disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how GBA1 genotype and sex relate to depression. REM sleep behavior disorder was associated with depression in GBA-PD, while sex, cognition, and motor...

P. Mitrotti, M. Avenali, C. Artusi et al. · npj Parkinson's Disease · 0 citations