Open access
Association of GBA1 status and sex with depression severity and progression in Parkinson's disease.
P. Mitrotti
M. Avenali
C. Artusi
Rosa De Micco
G. Giannini
R. Calabrese
Luca Gallo
C. Galandra
C. Ledda
Alice Mascia
M. Siciliano
Francesco Pagliuca
L. Sambati
Valeria Sant’Elia
G. Vornetti
Giovanna Calandra-Buonaura
Leonardo Lopiano
Raffaele Lodi
A. Tessitore
M. Bozzali
E. Valente
Medicine
Abstract
GBA1 variants increase neuropsychiatric vulnerability in Parkinson's disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how GBA1 genotype and sex relate to depression. REM sleep behavior disorder was associated with depression in GBA-PD, while sex, cognition, and motor complications were predictors in nonGBA-PD. Depressive symptoms were more severe and progressed faster in GBA-PD, supporting specific monitoring of this genetic subgroup.