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Author

E. Valente

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Open access Jul 2026

Association of GBA1 status and sex with depression severity and progression in Parkinson's disease.

GBA1 variants increase neuropsychiatric vulnerability in Parkinson's disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how GBA1 genotype and sex relate to depression. REM sleep behavior disorder was associated with depression in GBA-PD, while sex, cognition, and motor complications were predictors in nonGBA-PD. Depressive symptoms were more severe and progressed faster in GBA-PD, supporting specific monitoring of this genetic subgroup.

P. Mitrotti, M. Avenali, C. Artusi et al. · 0 citations