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GCH1 genetic variation as a prognostic factor in Parkinson disease across populations

J. Shin M. T. Periñán J. W. Jang L. Screven L. Lange C. Klein J. Shulman Z. Gan-Or M. G. Shahkhali K. Senkevich P. Dušek I. Miliukhina R. Alcalay C.-H. Lin R.-M. Wu H. Morris E.-K. Tan B.-R. Zhang G. Cogan A. Brice N. Mencacci I. Sarmiento T. Simuni S. B. Sassi M. Martí P. Pastor Yi-Wen Tay A. Tan S.-Y. Lim M. Stamelou F. Chafota M. Rentería W. Mohamed I. Mata M. Cornejo Olivas M. Cesarini A. Rivera M. Avenali E. Valente T. Foroud K. Nudelman M. Brumm T. Gasser
Aug 2026 · medRxiv · 0 citations
Medicine

TL;DR

GCH1 pathogenic variants were associated with a clinically distinct phenotype characterized by earlier disease onset and slower progression of motor complications, suggesting that GCH1 genetic variants may serve as genetic biomarkers for patient stratification and prognosis in PD.

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