M. T. Periñán

DNAJC13 Variants Show No Robust Association With Parkinson's Disease in a Multiancestry Cohort.

BACKGROUND DNAJC13 was initially linked to autosomal dominant (AD) Parkinson's disease (PD) in a European Mennonite family carrying the p.N855S variant. However, imperfect segregation and conflicting reports of pathogenicity raised uncertainty of the role of DNAJC13 in the disease. OBJECTIVE The objective for this study was to explore the association between common and rare variants in DNAJC13 and PD. METHODS We leveraged the largest available PD genetics data from the Accelerating Medicines Partnership-Parkinson Disease and the diverse ancestry available through the Global Parkinson's Genetics Program (GP2), consisting of 2471 patients and 3098 control subjects and 44,186 patients and 27,066 control subjects, respectively, to perform burden tests and association tests for rare and common variants, respectively. RESULTS Burden analysis showed no association between rare variants in DNAJC13 and PD. However, association analysis within common nonsynonymous variants nominated five variants within DNAJC13. Nevertheless, these associations require further investigation. CONCLUSIONS Our analysis did not find further evidence supporting DNAJC13 involvement in PD. However, studies of even larger cohorts and AD-PD families may bring definite answers about the role of DNAJC13 in PD. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

GCH1 genetic variation as a prognostic factor in Parkinson disease across populations

Cross-trait and multi-polytranscriptomic score analysis of Parkinson's disease identifies novel associations and improves prediction

Despite major progress in genomic risk loci identification, biological mechanisms underlying Parkinson's disease (PD) remain incompletely understood and the informativity of polygenic score (PGS)-based prediction remains modest. Polytranscriptomic scores (PTS) - the sum of an individual's observed gene expression weighted by transcriptome-wide association z-scores - combine the stability of genetics with the dynamic biology of gene expression and have the potential to identify associations not captured by genetics alone. We present the first large-scale cross-trait and multi-PTS analysis of PD, calculating ~550 PTS for 100 phenotypes using whole-blood RNA-seq data from three independent clinical cohorts in the Accelerating Medicines Partnership Parkinson's Disease programme (AMP-PD) (N = 2,741; NCASES = 1,644). We identify 26 Bonferroni significant cross-trait PTS associations with PD (p<9x10-5) involving 18 phenotypes and 11 trait categories, including neurodegenerative diseases, respiratory function, sleep and cardiovascular traits. Only one of these associations was observed using corresponding PGS, highlighting the added value of integrating directly measured transcriptomic data. Combining multiple PTS within machine learning multi-PTS models improved prediction of PD case/control status beyond age, sex and PD-PGS in external validation, with a sparse model including an additional seven PTS achieving an AUC of 0.74 [0.70-0.78], representing a 0.09-point improvement. These findings reveal transcriptomic overlap between PD and a range of clinically relevant traits, providing novel insights into disease biology with potential to improve disease prediction.