Author

Lai-Chuang Han

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Sep 2026

Structure-Guided Stepwise Engineering of a Microbial Glycosyltransferase for Highly Regioselective and Efficient Biosynthesis of Salidroside

Uridine diphosphate glycosyltransferases (UGTs) are among the key rate-limiting enzymes in the biosynthesis of salidroside. Plant-derived UGTs often exhibit poor solubility and low catalytic activity, whereas microbial UGTs typically show insufficient regioselectivity for salidroside production. In this study, we per...

Mu-Yang Li, Yi-Wei Meng, Ji-Shan Li et al. · ACS Catalysis · 0 citations

Open access Aug 2026

Creating a non-native bio-amidation activity in asparagine synthetase via biosensor-guided directed evolution for the synthesis of (S)-2-aminobutyramide

The direct asymmetric synthesis of chiral amides remains a focal point in green manufacturing, particularly for (S)-2-aminobutyramide whose traditional production is often hampered by low atom economy and arduous chiral resolution steps. Here, we report the creation of a non-native bio-amidation activity in Escherichia...

Qianpeng Lai, Yi-Wei Meng, Zhong-Mei Liu et al. · Chemical Science · 0 citations

#gene editing Aug 2026

Design of base editing systems with tunable editing hotspots within a defined window through sgRNA engineering.

Base editors (BEs) enable efficient A-to-G or C-to-T conversions without double-stranded DNA cleavage, but their editing windows remain difficult to tune, limiting genome engineering flexibility. Here, we engineered CRISPR/Cas12b sgRNA by introducing MS2 hairpins to recruit an MS2-N55K-cytidine deaminase-UGI complex, e...

Wen-Liang Hao, Lai-Chuang Han, Yao-Kang Wu et al. · Microbiology Research · 0 citations