Simplifying in silico protein evolution with minimal screening by unZipro.
UnZipro is presented, an efficient, scalable, and generalizable framework for zero-shot, in silico protein evolution, that integrates a compact, pre-trained inverse folding model with meta-learning to derive family-specific fitness landscapes.
Zhao-Hui Qin, Sanzeng Zhao, Zhao-Long Deng et al.
· Molecules and Cells · 1 citation