Author

Li-Hua Mo

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Open access Sep 2026

Antigen-specific regulatory T cells eliminate cognate CD4 effector T cells through perforin, granzyme B, and Bim.

T cells (Tregs) maintain immune tolerance, yet how they selectively eliminate cognate CD4+ effector T cells remains unclear. We propose a co-activation-dependent elimination mechanism, conceptually akin to synthetic lethality. Using in vitro co-cultures, we show that simultaneous peptide-MHC II recognition by Tregs and...

Yan-Yu Ye, Hao-Yue Zheng, Jia-Qi Duan et al. · Cell Reports · 0 citations

#protein folding Sep 2026

Targeting Mcl-1 to Restore IL-10-Driven Breg Suppression Reverses Allergic Asthma.

BACKGROUND Regulatory B cells (Bregs) suppress allergic inflammation primarily through interleukin-10 (IL-10), yet the intrinsic mechanisms constraining their regulatory capacity remain incompletely understood. Although the anti-apoptotic protein Mcl-1 is essential for B cell survival, its potential non-canonical roles...

Le Liu, Li-Hua Mo, Yan Feng et al. · Immunology Letters · 0 citations