Author

Lijuan Li

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Review Sep 2026

Immune-mediated thrombosis in myeloproliferative neoplasms: Pathogenic pathways and clinical relevance.

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic neoplasms characterized by a substantial risk of arterial and venous thrombosis, which remains a major cause of disease-related morbidity and mortality. Beyond abnormalities in blood-cell counts and rheology, MPN-associated thrombosis is increasingly recogniz...

Han-Lu Zhang, Hao Xiong, Xue-Ge Guo et al. · Leukemia research : a Forum... · 0 citations

#protein folding Open access Sep 2026

Engineered genomic attachment sites for site-specific recombinases enable high-efficiency integration in plants and human cells.

Here we developed a DNA-centric strategy for optimizing site-specific recombination by rationally engineering chimeric attachment sites. The high-activity att variants enhance Bxb1-mediated integration efficiency in human cells and plants. Among these att variants, the engineered attB(V111) site achieved 51.9% integrat...

Lin-Li Yan, Ling Zhou, Qiang Gao et al. · Nature Biotechnology · 0 citations

Review Open access Jul 2026

Beyond exhaustion: T cell fitness for next generation of immunotherapy for hematological cancer

T cell-directed immunotherapies have transformed the treatment of hematological malignancies, but durable benefit remains limited by relapse, poor persistence, incomplete immune reconstitution and infection. These outcomes depend not only on target-antigen expression but also on the functional quality of the T cell com...

Xiao-Shuang Kong, Yuan-Hui Su, Hanxue Zheng et al. · Frontiers in Immunology · 0 citations