Li-Qun Jin

Bee ovum-inspired hydrogel programs microenvironment remodeling for diabetic wound healing

A bee ovum-inspired hydrogel that mimics the parasitic wasp egg strategy, firm host adhesion and staged bioactive secretion, is designed, offering a promising approach for refractory diabetic wound therapy through microenvironment-responsive sequential treatment and upstream mitochondrial homeostasis restoration.

Transaminases engineering and their cascade systems for natural product synthesis.

Active Pocket Engineering of d-Tagatose 4-Epimerase for Improved Catalytic Performance and Efficient Cascade Synthesis of d-Tagatose from d-Glucose.

d-Tagatose is a rare hexose sugar with excellent properties, and its synthesis catalyzed by d-tagatose 4-epimerase (T4E) represents a competitive novel pathway. In this study, EbT4E derived from the Eubacteriales bacterium was screened and systematically characterized. By reshaping the microenvironment of the active po...