Transaminases engineering and their cascade systems for natural product synthesis.

A biocatalytic platform for the stereoselective synthesis of diverse atropisomeric compounds using engineered metalloenzymes

Atropisomeric compounds are widely distributed in natural products and pharmaceuticals and serve as key scaffolds in asymmetric catalysis. Despite their remarkable structural diversity, current synthetic efforts have primarily focused on C–C biaryl atropisomers, while the synthesis of other classes of atropisomeric com...

Thiamine diphosphate-dependent enzymes: mechanistic principles, stereoselective C-C bond formation, and synthetic biocatalytic applications.

This review systematically elucidates the structural characteristics, classification, and diverse reactions catalyzed by ThDP-dependent enzymes, with a primary focus on their potential for stereoselective C-C bond formation and cleavage.

Exploration of the Substrate Diversity of the Amine Transaminase 3FCR‐4M and its Engineered Variants

Enantioselective transamination of prochiral ketones is an indispensable transformation in the pharmaceutical and fine chemical industries. Transaminases have emerged as valuable biocatalysts for the preparation of a wide range of chiral amines through either kinetic resolution or asymmetric synthesis. Here, we explore...

Nitrene generation and transfer for unnatural biosynthesis in living cells.

It is shown that chemical reactions of metabolic intermediates produced intracellularly in living cells can include intermolecular nitrene transfers.

Advances in the Enzymic Synthesis of Unnatural Chiral Amino Acids.

Recent advances in synthesis and medicinal chemistry of pyrrolodiazepines

This review provides a systematic overview of the synthetic methodologies for pyrrolodiazepine derivatives that have been developed recently, encompassing transition-metal catalysis, cascade cyclization, multicomponent reactions, photoredox catalysis, base-mediated cyclization, and environmentally friendly synthesis ap...