Open access
Sep 2026
Cryo-EM structures of Candida albicans chitin synthase Chs1 reveal a druggable translocation channel.
Invasive candidiasis is a leading cause of hospital-acquired bloodstream infections with high mortality. While the fungal cell wall is an excellent therapeutic target, inhibitor development against the essential chitin synthase (Chs) has been hampered by the absence of structural and mechanistic understanding of class...
Zhenning Ren, Abhishek P. Chhetri, Chang Liu et al.
· Nature Microbiology · 0 citations