Author

Lian-Sheng Wang

3 papers indexed here

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Sep 2026

CCND1 Mitigates Ischemia-Induced Pathological Cardiac Remodeling by Promoting Cardiac Monocyte-Derived Macrophage Transition to a Reparative Phenotype.

BACKGROUND The innate immune system plays a pivotal role in orchestrating the response to myocardial infarction (MI), with monocytes and macrophages acting as central mediators of tissue injury and repair. Following MI, a dynamic sequence of inflammatory, anti-inflammatory, and reparative phases unfolds over the course...

Chu-Han Wang, Hui-An Han, Kai-Lai Li et al. · Circulation · 0 citations

Open access Sep 2026

ALDOC promotes cardiomyocyte proliferation and heart regeneration via suppressing RBM39-ubiquitination

AlDOC is a critical regulator of heart regeneration through the RBM39/PI3K/AKT pathway, and targeted activation of ALDOC or RBM39 represents a potential therapeutic strategy for myocardial injury.

Si-Bo Wang, Ting Zhu, Liu-Hua Zhou et al. · Cell Death & Disease · 0 citations

Review Jul 2026

Bench to Bedside: Insights from Large Animal Models and Emerging Clinical Trials of Endogenous Cardiac Regeneration and Repair

This review summarizes a range of intervention strategies designed to wake up cardiac regeneration and promote myocardial repair in the setting of residual following myocardial injury, and discusses the translational progress of these strategies.

Shu-Xuan Chen, Liu-Hua Zhou, Tong Yang et al. · Journal of Cardiovascular Tr... · 0 citations